Skip to main content
Open access
Original Article

Protective effect of recombinant human augmenter of liver regeneration on CCl4-induced hepatitis in mice

Published Online: 1998

Abstract

OBJECTIVE

To observe the anti-injury role of recombinant human augmenter of liver regeneration.

METHODS

To establish liver injury models induced by CCl4 in vivo and in vitro, cell survival rates and LDH release rates served as observing index in experiments in vitro. Survival rates of liver failure animals, serum concentration of ALT, LDH, DNA and pathological examination were selected as parameters in experiment in vivo.

RESULTS

rhALR could increase the survival rates and decrease the LDH release rates of injured hepatocytes in vitro. rhALR could also increase the survival rates of liver failure animal, promote hepatocyte proliferation and decrease the serum level of ALT and LDH in vivo.

CONCLUSIONS

ALR is an important stimulator for liver regeneration and may play important role in liver damage repair.

Formats available

You can view the full content in the following formats:

Information & Authors

Information

Published In

Go to Chinese Medical Journal homepage
Chinese Medical Journal
Volume 111Number 071998
Pages: 625 - 629

History

Published online: 24 September 2021

Permissions

Request permissions for this article.

Authors

Affiliations

Metrics & Citations

Metrics

VIEW ALL METRICS

Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

View Options

View options

Get Access

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

Figures and Media

Figures

Media

Tables

Share

Share

Share with email

Email a colleague

Share the article link

Share on social media

View PDF