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ALTERATION OF BLOOD DOPAMINE-BETA-HYDROXYLASE ACTIVITY IN PATIENTS WITH INTRAHEPATIC PORTAL HYPERTENSION

Published Online: 1982

Abstract

Assays of blood dopamine-beta-hydroxylase (DBH) activity are done by dual-wave length spectrophotometry. DBH activity is lower in cirrhotics than in normals in both the peripheral blood and splanchnic blood. These results suggest that an impediment in transforming dopamine into norepinephrine may exist in cirrhotics. The authors consider that the hyperdynamic circulation in patients with intrahepatic portal hypertension may be related to abnormal dopamine accumulation due to decreased DBH activity.

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Published In

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Chinese Medical Journal
Volume 95Number 101982
Pages: 737 - 740

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Published online: 4 September 2021

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Du Ru-yu
Department of Surgery, People's Hospital, Beijing Medical College, Beijing
Wang Xin-hui
Department of Surgery, People's Hospital, Beijing Medical College, Beijing
Huang Cui-ting
Department of Surgery, People's Hospital, Beijing Medical College, Beijing
Chen Juan
Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing

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